Inhba^em2Iimcb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Inhba^em2Iimcb
• Name: inhibin beta-A; endonuclease-mediated mutation 2, International Institute of Molecular and Cellular Biology in Warsaw
• MGI ID: MGI:8214990
• Gene: Inhba Location: Chr13:16186436-16206206 bp, + strand Genetic Position: Chr13, 5.85 cM
• Alliance: Inhba^em2Iimcb page

Mutation origin

• Strain of Origin: (C57BL/6JTar x CBA/WTar)F1

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Insertion
• Mutation details: The mutation involved the insertion of the left LoxP flank into the exon of 5 untranslated region of the first exon of the Inhba gene. The right LoxP sequence is located in the intron downstream of the Inhba gene, along with the XhoI sequence facilitating genotyping. The correct integration of LoxP sites was confirmed in the founder mouse by Sanger sequencing and routinely verified through mice genotyping. (J:368243)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inhba Mutation: 29 strains or lines available

References

• Original: J:368243 Winek E, Direct Data Submissions from the International Institute of Molecular and Cellular Biology in Warsaw. 2025
• All: 1 reference(s)