Matn4^em1Dbe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Matn4^em1Dbe
• Name: matrilin 4; endonuclease-mediated mutation 1, Dwight E Bergles
• MGI ID: MGI:8213635
• Synonyms: Matn4^mEGFP
• Gene: Matn4 Location: Chr2:164231313-164247080 bp, - strand Genetic Position: Chr2, 85.16 cM
• Alliance: Matn4^em1Dbe page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Using CRISPR-Cas9 technology, where Cas9 induced a double-stranded break at the start codon of the matrilin 4 (Matn4) gene, and the mEGFP sequence was inserted through homology-dependent repair (HDR). (J:101977, J:366858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Matn4 Mutation: 18 strains or lines available

References

• Original: J:366858 Heo D, et al., Transcriptional profiles of mouse oligodendrocyte precursor cells across the lifespan. Nat Aging. 2025 Apr;5(4):675-690
• All: 2 reference(s)