Romo1^tm1.1Xiwa
Targeted Allele Detail

Summary

• Symbol: Romo1^tm1.1Xiwa
• Name: reactive oxygen species modulator 1; targeted mutation 1.1, Xianhua Wang
• MGI ID: MGI:8211164
• Gene: Romo1 Location: Chr2:155986073-155987714 bp, + strand Genetic Position: Chr2, 77.36 cM
• Alliance: Romo1^tm1.1Xiwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:367536
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted around exon 2 and an FRT flanked neo cassette was inserted in intron 2 via homologous recombination. Cre mediated recombination removed exon 2. (J:367536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Romo1 Mutation: 14 strains or lines available

References

• Original: J:367536 Xu F, et al., ROMO1 overexpression protects the mitochondrial cysteinome from oxidations in aging. Nat Commun. 2025 Jun 3;16(1):5133
• All: 1 reference(s)