Inhba^em1Iimcb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Inhba^em1Iimcb
• Name: inhibin beta-A; endonuclease-mediated mutation 1, International Institute of Molecular and Cellular Biology in Warsaw
• MGI ID: MGI:8211126
• Gene: Inhba Location: Chr13:16186436-16206206 bp, + strand Genetic Position: Chr13, 5.85 cM
• Alliance: Inhba^em1Iimcb page

Mutation origin

• Strain of Origin: C57BL/6JTar

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: Loss-of-function mutation in coding exon 1 of the gene (c.129_130ins22bp, p.P44X - insertion of 22 bp between position 129 and 130 of cDNAtranscripts ID ENSMUST00000042603.13; ENSMUST00000164993.1). The insert cassette contains EcoRI enzyme digestion sequences and STOP codon, which cause premature translation arrest in each of the three possible ORF sequences and result in a frameshift mutation. (J:361667)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inhba Mutation: 30 strains or lines available

References

• Original: J:361667 Winek E, et al., Zygotic activin A is dispensable for the mouse preimplantation embryo development and for the derivation and pluripotency of embryonic stem cells. Biol Reprod. 2025 Jan 14;112(1):31-45
• All: 1 reference(s)