Arc^tm1.1Rsin
Targeted Allele Detail

Summary

• Symbol: Arc^tm1.1Rsin
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1.1, Robert H Singer
• MGI ID: MGI:8209045
• Synonyms: Arc^P, Arc-PBS
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1.1Rsin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:367232
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a 1.5-kbp cassette containing 24 repeats of the bacteriophage PP7 binding sites (PBS) stem-loop motif, followed by a Frt-flanked neo cassette into the 3' untranslated region of the Arc gene. Frt-flanked neo cassette was removed by Flp recombinase. (J:367232)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 34 strains or lines available

References

• Original: J:367232 Das S, et al., A transgenic mouse for imaging activity-dependent dynamics of endogenous Arc mRNA in live neurons. Sci Adv. 2018 Jun;4(6):eaar3448
• All: 1 reference(s)