Rr562484^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Rr562484^tm1.1Meg
• Name: regulatory region 562484; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:8189938
• Synonyms: TMKI
• Gene: Rr562484 Location: Chr2:109522291-109522791 bp, . strand Genetic Position: Chr2, Syntenic
• Alliance: Rr562484^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Nucleotide substitutions
• Mutation details: Mutations were introduced in the CaRE1 (CTATTTCG>ACTCCGCC), CaRE2 (ATCATATGA>TAAGATGAC), and CaRE3/CRE (TCACGT>CAGCTG) elements of the alternative non-coding 5' UTR exon IV promoter. A loxP site flanked neomycin/zeomycin resistance gene cassette that was inserted downstream of alternative exon VII was deleted through Cre-mediated recombination. (J:278700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr562484 Mutation: 0 strains or lines available

References

• Original: J:278700 Hong EJ, et al., A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron. 2008 Nov 26;60(4):610-24
• All: 1 reference(s)