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Lmod1em2Jomm
Endonuclease-mediated Allele Detail
Summary
Symbol: Lmod1em2Jomm
Name: leiomodin 1 (smooth muscle); endonuclease-mediated mutation 2, Joseph M Miano
MGI ID: MGI:8174731
Synonyms: CArG-Mut
Gene: Lmod1  Location: Chr1:135252551-135295803 bp, + strand  Genetic Position: Chr1, 58.51 cM, cytoband F
Alliance: Lmod1em2Jomm page
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/Cas9 technology targeting the two CArG elements within the proximal promoter generated a CTT to GGG change in the first CArG box and CTA to GGG change in the second CArG box. RT-PCR showed reduced expression in aorta, but no difference in other tissues. Western blot analysis showed no difference in protein levels in bladder or aorta. (J:241933)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmod1 Mutation:  29 strains or lines available
References
Original:  J:241933 Halim D, et al., Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2739-E2747
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory