Mapt^em2Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mapt^em2Lutzy
• Name: microtubule-associated protein tau; endonuclease-mediated mutation 2, Cathy Lutz
• MGI ID: MGI:8166666
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^em2Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The allele was generated using CRISPR/Cas9 endonuclease-mediated genome editing using guide RNAs selected to target exon 9 of the microtubule-associated protein tau locus (Mapt) on Chromosome 11. Donor DNAs were created encoding a proline-to-leucine mutation P290L (CCG->CTG) and a silent point mutation V289V (GTC->GTT). (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 457 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)