Snca^em2Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Snca^em2Lutzy
• Name: synuclein, alpha; endonuclease-mediated mutation 2, Cathy Lutz
• MGI ID: MGI:8166665
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^em2Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The allele was generated using CRISPR/Cas9 endonuclease-mediated genome editing by using guide RNAs selected to target exon 2 of the synuclein, alpha locus (Snca) on Chromosome 6. Donor DNAs were created encoding a alanine-to-proline mutation A30P (GCT>CCT) and a silent point mutation E28E (GAG>GAA). (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 49 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)