Zfp768^em1Mala
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp768^em1Mala
• Name: zinc finger protein 768; endonuclease-mediated mutation 1, Mathieu Laplante
• MGI ID: MGI:8164214
• Synonyms: Znf768^-
• Gene: Zfp768 Location: Chr7:126941967-126944486 bp, - strand Genetic Position: Chr7, 69.47 cM
• Alliance: Zfp768^em1Mala page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of the first exon generated a 17 bp deletion causing a frame shift in Znf768 sequence and the premature disruption of the coding sequence. Western blot and immunohistochemistry confirmed the absence of protein expression in several tissues (kidney, lung, liver and thymus) from homozygous mutant mice. (J:363750)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp768 Mutation: 18 strains or lines available

References

• Original: J:363750 Poirier A, et al., ZNF768 loss amplifies p53 action and reduces lung tumorigenesis in mice. Oncogene. 2025
• All: 1 reference(s)