Ppp2r5b^em2Bmc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppp2r5b^em2Bmc
• Name: protein phosphatase 2, regulatory subunit B', beta; endonuclease-mediated mutation 2, Brent McCright
• MGI ID: MGI:8161231
• Synonyms: B56beta null, B79-, b79 null
• Gene: Ppp2r5b Location: Chr19:6277795-6285902 bp, - strand Genetic Position: Chr19, 4.35 cM
• Alliance: Ppp2r5b^em2Bmc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 41 bp deletion in exon 2. Western blot analysis confirmed the absence of wild-type protein expression in brain extracts from homozygous mutant neonates. (J:348684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r5b Mutation: 18 strains or lines available

References

• Original: J:348684 Dyson JJ, et al., Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. FASEB Bioadv. 2022 Apr;4(4):273-282
• All: 1 reference(s)