Gt(ROSA)26Sor^{em4(CAG-BMPR1A*,-Venus)Akg}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em4(CAG-BMPR1A*,-Venus)Akg}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Andrew K Groves
• MGI ID: MGI:7869451
• Synonyms: BMPR-QD
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em4(CAG-BMPR1A*,-Venus)Akg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em4(CAG-BMPR1A*,-Venus)Akg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BMPR1A (657)

  Bmpr1a

  (MGI:1338938)

• Mutation details: Using CRSPR technology, the human BMPR1A coding sequence with a constitutively active Q233D mutant followed by a GSG-P2A and coding region of the Venus fluorescent protein were inserted into Gt(ROSA)26Sor downstream of CAG promoter followed by loxp-STOP. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1032 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)