Tyk2^em1Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tyk2^em1Mbp
• Name: tyrosine kinase 2; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:7867586
• Gene: Tyk2 Location: Chr9:21015364-21042539 bp, - strand Genetic Position: Chr9, 7.71 cM, cytoband A3
• Alliance: Tyk2^em1Mbp page

Mutation origin

• Strain of Origin: C57BL/6N-Tmprss2^{em1(TMPRSS2)Mbp} Ace2^em1(ACE2)Mbp/Mmucd

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting mutated residue codon CCC to GCC at the 1124th residue as well as two silent mutations were engineered into the HDR template totaling 3 mismatches to prevent RNP re-cleavage. Tyk2_P1124A was created in the mouse to model the human coding variant TYK2_P1104A caused by rs34536443. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyk2 Mutation: 69 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)