Plscr1^em1Mbp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plscr1^em1Mbp
• Name: phospholipid scramblase 1; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:7867581
• Synonyms: Plscr_Q271Y
• Gene: Plscr1 Location: Chr9:92132265-92154034 bp, + strand Genetic Position: Chr9, 48.35 cM, cytoband E3.3
• Alliance: Plscr1^em1Mbp page

Mutation origin

• Strain of Origin: C57BL/6N-Tmprss2^{em1(TMPRSS2)Mbp} Ace2^em1(ACE2)Mbp/Mmucd

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting mutated residue codon CAG to TAT at the 271th residue were engineered into the HDR template totaling 2 guide mismatches to prevent RNP re-cleavage Q271Y was created in the mouse to model the human coding variant PLSCR_H262Y caused by rs343320. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plscr1 Mutation: 30 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)