Ace2^{em2(ACE2*D355N)Mbp}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^{em2(ACE2*D355N)Mbp}
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:7867579
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^{em2(ACE2*D355N)Mbp} page

Mutation origin

• Strain of Origin: C57BL/6N-Tmprss2^{em1(TMPRSS2)Mbp} Ace2^em1(ACE2)Mbp/Mmucd

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Ace2^{em2(ACE2*D355N)Mbp} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

  D355N mutation

• Mutation details: CRISPR-targeting mutated residue codon GAC to AAT at the 355th residue of the human CDS were engineered into the HDR template totaling 2 guide mismatches to prevent RNP re-cleavage. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 72 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)