Trpv4^em1Dhco
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpv4^em1Dhco
• Name: transient receptor potential cation channel, subfamily V, member 4; endonuclease-mediated mutation 1, Daniel H Cohn
• MGI ID: MGI:7861782
• Synonyms: Trpv4(p.R594H)
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^em1Dhco page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Humanized sequence)
• Mutation: Insertion
• Mutation details: A CRISPR/Cas9 generated mutation that results in the insertion of a loxP flanked cassette containing murine cDNA encoding exons 11-16 of Trpv4 into intron 10 of the endogenous gene. An arginine to histidine (R594H) missense mutation was also created in endogenous exon 11, downstream of the cDNA cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 58 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)