Gt(ROSA)26Sor^{tm2(TARDBP)Tlbt}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(TARDBP)Tlbt}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Kevin Talbot
• MGI ID: MGI:7859507
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(TARDBP)Tlbt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265544
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This allele expresses a single copy of a bacterial artificial chromosome (BAC) construct carrying the entire genomic locus of the human wild-type TARDBP (TDP-43) gene inserted into the mouse endogenous Gt(ROSA)26Sor locus. Human wild-type TDP-43 is expressed at low levels on a background of mouse endogenous TDP-43. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

Notes

embryonic stem cell line = IDG26.10-3

References

• Original: J:265544 Gordon D, et al., Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. Neurobiol Dis. 2018 Oct 2;121:148-162
• All: 2 reference(s)