Gt(ROSA)26Sor^em3(MAPT)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^em3(MAPT)H
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 3, Harwell
• MGI ID: MGI:7859328
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^em3(MAPT)H page

Mutation origin

• Strain of Origin: 129S9/SvEvH

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The allele carries a MOE (Multi-level Over Expression) allele with coding sequence for MAPT which enables conditional expression via Cre-LoxP excisable stop cassette, switchable promotor via Flp-FRT recombination which removes the stronhger CAG promotor and depends on the lower ROSA 26 promoter expression and WPRE (Woodchuck hepatitis virus posttranscriptional regulatory element) transcript stabilising element excisable via Dre-RoxP recombination . (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)