Prkg1^tm1Cya
Targeted Allele Detail

Summary

• Symbol: Prkg1^tm1Cya
• Name: protein kinase, cGMP-dependent, type I; targeted mutation 1, Cyagen Biosciences
• MGI ID: MGI:7859311
• Gene: Prkg1 Location: Chr19:30541889-31742433 bp, - strand Genetic Position: Chr19, 25.17 cM, cytoband C2
• Alliance: Prkg1^tm1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:361510
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct introduced the mutation ( c.797A to T NM_001013833) responsible for the amino acid substitution of cysteine with serine at position 195 (C195S). An FRT flanked neomycin resistance cassette was also inserted into intron 3. (J:361510)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prkg1 Mutation: 65 strains or lines available

References

• Original: J:361510 Kamynina A, et al., Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I. Hypertension. 2022 May;79(5):946-956
• All: 1 reference(s)