Azin1^em2Hato
Endonuclease-mediated Allele Detail

Summary

• Symbol: Azin1^em2Hato
• Name: antizyme inhibitor 1; endonuclease-mediated mutation 2, Takashi Hato
• MGI ID: MGI:7857186
• Synonyms: Azin1 A-to-I uneditable
• Gene: Azin1 Location: Chr15:38487674-38523506 bp, - strand Genetic Position: Chr15, 15.17 cM, cytoband C
• Alliance: Azin1^em2Hato page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A CRISPR-generated AGC/serine to TCC/serine) mutation was introduced to the adenosine-to-inosine (A-to-I) mRNA editing site within the mouse Azin1 coding sequence. A silent mutation was also introduced at the PAM site (GTG/valine to TGC/valine). (J:361327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Azin1 Mutation: 27 strains or lines available

References

• Original: J:361327 Heruye SH, et al., Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing. J Clin Invest. 2024 Sep 3;134(17)
• All: 1 reference(s)