Ism1^em2Nusrg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ism1^em2Nusrg
• Name: isthmin 1, angiogenesis inhibitor; endonuclease-mediated mutation 2, Ruowen Ge
• MGI ID: MGI:7856634
• Synonyms: Ism1^em2Fgnx, Ism1^tm23Nusrg
• Gene: Ism1 Location: Chr2:139520098-139600501 bp, + strand Genetic Position: Chr2, 69.06 cM
• Alliance: Ism1^em2Nusrg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing of exon1 deleted 23 bp, resulting in an out-of-frame mutation and no protein produced in a whole body knockout fashion. (J:342380)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ism1 Mutation: 31 strains or lines available

References

• Original: J:342380 Lam TYW, et al., ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2019161119
• All: 3 reference(s)