Tg(Rr596*-EGFP)nPE1Low
Transgene Detail

Summary

• Symbol: Tg(Rr596*-EGFP)nPE1Low
• Name: transgene insertion nPE1, Malcolm J Low
• MGI ID: MGI:7855595
• Synonyms: nPE1Pomc-EGFP
• Transgene: Tg(Rr596*-EGFP)nPE1Low Location: unknown
• Alliance: Tg(Rr596*-EGFP)nPE1Low page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the following: the Pomc gene, including sequence 8 kb downstream of the transcription start site and 13 kb upstream (minus the -6.5 to -0.8 kb region), containing pituitary-specific enhancer Rr281 but with neuron-specific enhancer Rr280 (nPE2) deleted (172 bp) and Rr279 (nPE1) still present, and the promoter, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. (J:224010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:224010 Lam DD, et al., Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. PLoS Genet. 2015 Feb;11(2):e1004935
• All: 1 reference(s)