Mecp2^{tm2(MECP2*)Cya}
Targeted Allele Detail

Summary

• Symbol: Mecp2^{tm2(MECP2*)Cya}
• Name: methyl CpG binding protein 2; targeted mutation 2, Cyagen Biosciences
• MGI ID: MGI:7797877
• Synonyms: Mecp2^{tm2(hMECP2*T158M)}
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^{tm2(MECP2*)Cya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mecp2^{tm2(MECP2*)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MECP2 (4204)

  Mecp2

  (MGI:99918)

  MECP2*T158M

• Mutation details: The endogenous mouse domain (aa.10-484) is replaced by the corresponding human domain (aa.10-486). Additionally, a point mutation, T158M (ACG to ATG), is introduced into exon 4 of the human gene. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 46 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)