Smpd3^em1Rstot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smpd3^em1Rstot
• Name: sphingomyelin phosphodiesterase 3, neutral; endonuclease-mediated mutation 1, Rolf Stottmann
• MGI ID: MGI:7797831
• Synonyms: Smpd3^del
• Gene: Smpd3 Location: Chr8:106979180-107064597 bp, - strand Genetic Position: Chr8, 53.12 cM, cytoband D2
• Alliance: Smpd3^em1Rstot page

Mutation origin

• Strain of Origin: C57BL6/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9 genome editing technology was used to generate a large 9,514 base-pair deletion corresponding to exons 3-7 of the gene. (J:359862)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smpd3 Mutation: 47 strains or lines available

References

• Original: J:359862 Inskeep KA, et al., SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development. Development. 2024 Nov 15;151(22)
• All: 1 reference(s)