Il6^tm2(IL6)Smoc
Targeted Allele Detail

Summary

• Symbol: Il6^tm2(IL6)Smoc
• Name: interleukin 6; targeted mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7786886
• Synonyms: Il6^{tm1(hIL6)Smoc}
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm2(IL6)Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Il6^tm2(IL6)Smoc expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting. (J:238766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 41 strains or lines available

References

• Original: J:238766 Shanghai Model Organisms Center, Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China. MGI Direct Data Submission. 2017
• All: 1 reference(s)