Astn2^em2Hatn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Astn2^em2Hatn
• Name: astrotactin 2; endonuclease-mediated mutation 2, Mary E Hatten
• MGI ID: MGI:7786605
• Synonyms: Astn2^-
• Gene: Astn2 Location: Chr4:65299040-66322774 bp, - strand Genetic Position: Chr4, 34.31 cM, cytoband C1
• Alliance: Astn2^em2Hatn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 methodologies ~3 kb of the promoter and exon 1, encoding the ATG start codon of the mouse Astn2 gene, was excised in C57BL/6J embryos. (J:359224)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Astn2 Mutation: 60 strains or lines available

References

• Original: J:359224 Hanzel M, et al., Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2405901121
• All: 1 reference(s)