Snx14^em1Naki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Snx14^em1Naki
• Name: sorting nexin 14; endonuclease-mediated mutation 1, Naiara Akizu
• MGI ID: MGI:7785458
• Synonyms: Snx14^-, Snx14-KO
• Gene: Snx14 Location: Chr9:88258805-88320982 bp, - strand Genetic Position: Chr9, 47.24 cM
• Alliance: Snx14^em1Naki page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 gene editing technology, sgRNA (5-GTAAACACGTTCTCCAAC-3) was designed to introduce deletion of 1bp in exon 14 of Snx14 (c.1432delG;p.Glu478Argfs*18) to generates a premature stop codon. (J:353340)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snx14 Mutation: 52 strains or lines available

References

• Original: J:353340 Zhou Y, et al., Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency. JCI Insight. 2024 Apr 16;9(10)
• All: 1 reference(s)