Smchd1^tm1.1Mebl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Smchd1^tm1.1Mebl
• Name: SMC hinge domain containing 1; targeted mutation 1.1, Marnie E Blewitt
• MGI ID: MGI:7785212
• Synonyms: Smchd1^GFP
• Gene: Smchd1 Location: Chr17:71651484-71782338 bp, - strand Genetic Position: Chr17, 41.87 cM
• Alliance: Smchd1^tm1.1Mebl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299032
• Parent Cell Line: C1368 (ES Cell)
• Strain of Origin: 129T2/SvEms

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: An acGFP-loxP-neomycin resistance-loxP cassette was introduced in-frame immediately before the stop codon. The neomycin resistance gene was removed via cre-mediated recombination generating a Smchd1-acGFP fusion. (J:299032)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smchd1 Mutation: 144 strains or lines available

References

• Original: J:299032 Jansz N, et al., Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters. Nat Struct Mol Biol. 2018 Sep;25(9):766-777
• All: 3 reference(s)