Qrich1^em1Nki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Qrich1^em1Nki
• Name: glutamine-rich 1; endonuclease-mediated mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:7785048
• Synonyms: QRICH1^deltaCARD
• Gene: Qrich1 Location: Chr9:108394010-108437366 bp, + strand Genetic Position: Chr9, 59.45 cM
• Alliance: Qrich1^em1Nki page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: Deletion of CARD domain was achieved through an in-frame 144bp deletion (TCATTTGAAGAGTACATCCGAGTAAAGGCGAGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCTTCTAAGGGACCAGAAGCTCTTCAGGAGTTCCAGCAGACTGCCACCACCACCATGGTGTACCAGCAG), between two CRISPR/Cas9 target sequences: 5'-GATGTACTCTTCAAATGAGA TGG-3' and 5'-CCATGGTGTACCAGCAGGGT GGG-3'. (J:369749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qrich1 Mutation: 60 strains or lines available

References

• Original: J:369749 Bianchi D, et al., Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression. Science. 2025 Jul 3;389(6755):eadv2861
• All: 1 reference(s)