Lox^em1.1Rivp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lox^em1.1Rivp
• Name: lysyl oxidase; endonuclease-mediated mutation 1.1, Roberto I Vazquez-Padron
• MGI ID: MGI:7783638
• Synonyms: Lox^f
• Gene: Lox Location: Chr18:52649139-52662939 bp, - strand Genetic Position: Chr18, 28.22 cM
• Alliance: Lox^em1.1Rivp page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1, a second loxP site and FRT-flanked neomycin selection cassette and ROX site were inserted downstream of exon 2, and a second ROX site was inserted downstream of exon 3. The neomycin selection cassette was removed via flp-mediated recombination leaving exons 1-2 floxed and exon 3 flanked by ROX sites. (J:358805)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lox Mutation: 23 strains or lines available

References

• Original: J:358805 Stoyell-Conti FF, et al., Gene inactivation of lysyl oxidase in smooth muscle cells reduces atherosclerosis burden and plaque calcification in hyperlipidemic mice. Atherosclerosis. 2024 Oct;397:118582
• All: 1 reference(s)