Tg(EEF1A1-CHRFAM7A)3Elic
Transgene Detail

Summary

• Symbol: Tg(EEF1A1-CHRFAM7A)3Elic
• Name: transgene insertion 3, Brian Eliceiri
• MGI ID: MGI:7782583
• Synonyms: Tg(EF1A-CHRFAM7A)3Elic
• Transgene: Tg(EEF1A1-CHRFAM7A)3Elic Location: unknown
• Alliance: Tg(EEF1A1-CHRFAM7A)3Elic page

Transgene origin

• Strain of Origin: C57BL/6JCya

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(EEF1A1-CHRFAM7A)3Elic expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHRFAM7A (89832)

  Chrna7

  (MGI:99779)

• Tg(EEF1A1-CHRFAM7A)3Elic expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  EEF1A1 (1915)

  Eef1a1

  (MGI:1096881)

• Mutation details: A human full-length CHRFAM7A (Variant 1: NM_139320.1) gene is expressed under the control of a human EF1A promoter. Lines 3 and 4 were generated. (J:274310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:274310 Costantini TW, et al., Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7932-7940
• All: 2 reference(s)