Cyth1^m1J
Spontaneous Allele Detail

Summary

• Symbol: Cyth1^m1J
• Name: cytohesin 1; mutation 1, Jackson
• MGI ID: MGI:7781810
• Synonyms: Cyth1^BALB/cByJ
• Gene: Cyth1 Location: Chr11:118054996-118139452 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Cyth1^m1J page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Cyth1^m1J involves 1 genes/genome features (Cyth1) View all
• Mutation details: This 37.6 kb deletion of Chr11:118,050,607118,088,208 (GRCm39) from within the first intron of the Cyth1 gene to 4.4 kb 3 of the last Cyth1 exon results in a null allele but also impacts the expression of the downstream Dnah17 via readthrough transcript generation that is not predicted to result in stable protein expression. This deletion is a strain characteristic of BALB/cByJ but is not present in BALB/cJ. (J:357385)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyth1 Mutation: 75 strains or lines available

References

• Original: J:357385 Song R, et al., A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy. Sci Rep. 2024 Jun 10;14(1):13333
• All: 1 reference(s)