Ppif^em1Cask
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppif^em1Cask
• Name: peptidylprolyl isomerase F (cyclophilin F); endonuclease-mediated mutation 1, Kevin M Casin
• MGI ID: MGI:7779593
• Synonyms: CyPD^R96G
• Gene: Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
• Alliance: Ppif^em1Cask page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination created an R96G mutation resulting in expression of a prolyl isomerase dead version of the protein. Homozygous mice show significantly reduced prolyl isomerase activity and reduced levels of the mutant protein in the mitochondria. (J:358023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppif Mutation: 18 strains or lines available

References

• Original: J:358023 Casin KM, et al., Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2023 Oct;183:67-69
• All: 1 reference(s)