Ppifem1Cask
Endonuclease-mediated Allele Detail
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Symbol: |
Ppifem1Cask |
Name: |
peptidylprolyl isomerase F (cyclophilin F); endonuclease-mediated mutation 1, Kevin M Casin |
MGI ID: |
MGI:7779593 |
Synonyms: |
CyPDR96G |
Gene: |
Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
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Alliance: |
Ppifem1Cask page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Hypomorph) |
Mutation: |
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Nucleotide substitutions
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Mutation details: CRISPR/cas9 mediated recombination created an R96G mutation resulting in expression of a prolyl isomerase dead version of the protein. Homozygous mice show significantly reduced prolyl isomerase activity and reduced levels of the mutant protein in the mitochondria.
(J:358023)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ppif Mutation: |
18 strains or lines available
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Original: |
J:358023 Casin KM, et al., Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury. J Mol Cell Cardiol. 2023 Oct;183:67-69 |
All: |
1 reference(s) |
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