Kcnh7^em2Hhtg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnh7^em2Hhtg
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 7; endonuclease-mediated mutation 2, Irm Hermans-Borgmeyer
• MGI ID: MGI:7778467
• Synonyms: erg3^-
• Gene: Kcnh7 Location: Chr2:62524428-63014980 bp, - strand Genetic Position: Chr2, 36.5 cM
• Alliance: Kcnh7^em2Hhtg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination generated a 649 bp deletion of exon 5 that leads to a premature stop codon after 316 amino acids. Western blot analysis confirmed the absence of protein in brain extracts. (J:358013)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh7 Mutation: 59 strains or lines available

References

• Original: J:358013 Schwarz JR, et al., Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-a-go-go-related gene) K(+) channel subunits. Sci Adv. 2024 Oct 4;10(40):eadn6836
• All: 1 reference(s)