Kat6a^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Kat6a^tm1Ics
• Name: K(lysine) acetyltransferase 6A; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:7764753
• Synonyms: KAT6A^FL
• Gene: Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Kat6a^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357666
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct floxed exon 4. (J:357666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6a Mutation: 69 strains or lines available

References

• Original: J:357666 Sheridan M, et al., The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency. J Hematol Onco. 2024;17(1):91
• All: 1 reference(s)