Shank3^em1Yhj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Shank3^em1Yhj
• Name: SH3 and multiple ankyrin repeat domains 3; endonuclease-mediated mutation 1, Yong-hui Jiang
• MGI ID: MGI:7738562
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^em1Yhj page

Mutation origin

• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site upstream of exon 4 and a second loxP site upstream of exon 10 of the Shank3 gene flanking exons 4-9 and the third loxP site 5-kb downstream of exon 22 generated in Shank3^tm2.1Yhj was targetted by CRISPR/cas9 methodologies to remove the second loxP site. Only two loxP sites flanking exons 4-22 of the Shank3 gene remain, one loxp between exon 3 and exon 4, and another loxp after exon 22. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 87 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)