Gpr4^em1Daba
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr4^em1Daba
• Name: G protein-coupled receptor 4; endonuclease-mediated mutation 1, Douglas A Bayliss
• MGI ID: MGI:7736374
• Synonyms: GPR4-H81F, GPR4^H81F
• Gene: Gpr4 Location: Chr7:18946463-18958099 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gpr4^em1Daba page

Mutation origin

• Strain of Origin: B6SJLF1/J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology was used to introduce H81F (CAC > TTT) point mutations into Gpr4. A cytosine to thymidine mutation was also included to disrupt a BamH1 restriction site. (J:101977, J:354640)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr4 Mutation: 26 strains or lines available

References

• Original: J:354640 Gonye EC, et al., Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO(2)-Stimulated Breathing. J Neurosci. 2024 Sep 4;44(36)
• All: 2 reference(s)