Isr(HSA11;CD3D,CD3E,CD3G)1Smoc
Targeted Allele Detail

Summary

• Symbol: Isr(HSA11;CD3D,CD3E,CD3G)1Smoc
• Name: interspecies replacement, human Chr 11, Shanghai Model Organisms Center 1
• MGI ID: MGI:7734932
• Synonyms: Cd3e^tm1(hCD3E) Cd3d^tm1(hCD3D) Cd3g^tm1(hCD3G), In(9CD3D,CD3E,CD3G)1Smoc
• Gene: Isr(HSA11;CD3D,CD3E,CD3G)1Smoc Location: unknown Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:359311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Isr(HSA11;CD3D,CD3E,CD3G)1Smoc involves 3 genes/genome features (Cd3g, Cd3d, Cd3e) View all
• Isr(HSA11;CD3D,CD3E,CD3G)1Smoc expresses 3 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD3D (915)

  Cd3d	(MGI:88331)

  human

  CD3E (916)

  Cd3e	(MGI:88332)

  human

  CD3G (917)

  Cd3g	(MGI:88333)

• The mouse genes were replaced with human genes. (J:359311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isr(HSA11;CD3D,CD3E,CD3G)1Smoc Mutation: 0 strains or lines available

References

• Original: J:359311 Lin F, et al., Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment. Cell. 2024 Nov 2
• All: 1 reference(s)