Mir96^tm3.1Wtsi
Targeted Allele Detail

Summary

• Symbol: Mir96^tm3.1Wtsi
• Name: microRNA 96; targeted mutation 3.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:7720056
• Synonyms: Mir96^+14CtoA, Mir96^{tm3.2(IMPC)Wtsi}, Mir96^tm3.2Wtsi
• Gene: Mir96 Location: Chr6:30169445-30169550 bp, - strand Genetic Position: Chr6, 12.52 cM
• Alliance: Mir96^tm3.1Wtsi page

Mutation origin

• Mutant Cell Line: BEPD0003_D07
• Germline Transmission: Earliest citation of germline transmission: J:355683
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation Vector: L1L2_Bact_P
• Mutation details: The molecular lesion is a C-to-A point mutation at nucleotide 29. Flp-mediated recombination of the parental Mir96^tm3Wts allele removed the selection cassette. (J:355683)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir96 Mutation: 8 strains or lines available

References

• Original: J:355683 Lewis MA, et al., Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations. Genome Med. 2024 Oct 21;16(1):121
• All: 2 reference(s)