Cxcl16^em1Xiaow
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cxcl16^em1Xiaow
• Name: C-X-C motif chemokine ligand 16; endonuclease-mediated mutation 1, Xiaoxiao Wan
• MGI ID: MGI:7716924
• Synonyms: Cxcl16^-
• Gene: Cxcl16 Location: Chr11:70345215-70350810 bp, - strand Genetic Position: Chr11, 42.99 cM, cytoband B4
• Alliance: Cxcl16^em1Xiaow page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Guide RNAs (CCAGATACCGCAGGGTACTTNGG and TCTGGCACCCAGATACCGCANGG) were designed to create a 13 bp deletion in exon 2 of the C-X-C motif chemokine ligand 1 (Cxcl16) gene. (J:349428)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl16 Mutation: 23 strains or lines available

References

• Original: J:349428 Srivastava N, et al., CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity. Immunity. 2024 May 6
• All: 1 reference(s)