Rr545^em2Tboz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr545^em2Tboz
• Name: regulatory region 545; endonuclease-mediated mutation 2, Thomas Bozza
• MGI ID: MGI:7714933
• Synonyms: deltaTE1/2
• Gene: Rr545 Location: Chr10:23863682-23864027 bp Genetic Position: Chr10, Syntenic
• Alliance: Rr545^em2Tboz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Taar cluster enhancer, located between Taar6 and Taar7a, was targeted using sgRNAs with CRISPR/Cas9 technology, resulting in a 979 bp deletion (GRCm39:chr10:23,863,677-23,864,655). The allele was created in zygotes heterozygous for the Taar1^tm1Tboz and Taar4^tm1.1Tboz alleles. The allele was created in conjunction with the Rr544^em2Tboz allele and Taar4^tm1.1Tboz Rr544^em2Tboz Rr545^em2Tboz mice were selected for experiments. (J:343906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr545 Mutation: 0 strains or lines available

References

• Original: J:343906 Shah A, et al., Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers. Nat Commun. 2021 Jun 18;12(1):3797
• All: 1 reference(s)