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Rr366694em1Ndav
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr366694em1Ndav
Name: regulatory region 366694; endonuclease-mediated mutation 1, Nadav Ahituv
MGI ID: MGI:7711741
Synonyms: Xe1 KO
Gene: Rr366694  Location: Chr2:147402075-147403763 bp, + strand  Genetic Position: Chr2, Syntenic
Alliance: Rr366694em1Ndav page
Mutation
origin
Strain of Origin:  Not Applicable
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intergenic deletion
 
Mutation detailsPax1 enhancer Xe1 was targeted using sgRNAs (equivalent to GAACTTAAGTGGTGGAGTCGAGG and ACTCATTTGCCAAGACCCATGGG) with CRISPR/Cas9 technology, resulting in ~3.2 kb deletions. Three strains were produced with the following deletions: GRCm39:chr2:147401677-147404891 (129-A), 147401678-147404882 (127-C), 147401675-147404886 (123-B). (J:346374)
Expression
In Mice Carrying this Mutation: 20 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr366694 Mutation:  0 strains or lines available
References
Original:  J:346374 Ushiki A, et al., Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality. Cell Rep. 2024 Mar 8;43(3):113907
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory