Rr366694em1Ndav
Endonuclease-mediated Allele Detail
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Symbol: |
Rr366694em1Ndav |
Name: |
regulatory region 366694; endonuclease-mediated mutation 1, Nadav Ahituv |
MGI ID: |
MGI:7711741 |
Synonyms: |
Xe1 KO |
Gene: |
Rr366694 Location: Chr2:147402075-147403763 bp, + strand Genetic Position: Chr2, Syntenic
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Alliance: |
Rr366694em1Ndav page
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Strain of Origin: |
Not Applicable
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutation: |
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Intergenic deletion
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Mutation details: Pax1 enhancer Xe1 was targeted using sgRNAs (equivalent to GAACTTAAGTGGTGGAGTCGAGG and ACTCATTTGCCAAGACCCATGGG) with CRISPR/Cas9 technology, resulting in ~3.2 kb deletions. Three strains were produced with the following deletions: GRCm39:chr2:147401677-147404891 (129-A), 147401678-147404882 (127-C), 147401675-147404886 (123-B).
(J:346374)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr366694 Mutation: |
0 strains or lines available
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Original: |
J:346374 Ushiki A, et al., Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality. Cell Rep. 2024 Mar 8;43(3):113907 |
All: |
1 reference(s) |
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