Dusp26^tm1Miv
Targeted Allele Detail

Summary

• Symbol: Dusp26^tm1Miv
• Name: dual specificity phosphatase 26; targeted mutation 1, Nahid F Mivechi
• MGI ID: MGI:7710877
• Synonyms: dusp26^-, Dusp26-KO
• Gene: Dusp26 Location: Chr8:31579555-31587074 bp, + strand Genetic Position: Chr8, 17.93 cM, cytoband A3
• Alliance: Dusp26^tm1Miv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:353273
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector was designed to insert a beta-galactosidase gene (lacZ) immediately downstream of the ATG start codon (exon 3) of the dual specificity phosphatase 26 (Dusp26) gene via homologous recombination in ES cells. The construct also contained a loxP-flanked neomycin cassette following the LacZ sequence. The insertion results in the ablation of endogenous Dusp26 expression. (J:353273)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dusp26 Mutation: 22 strains or lines available

References

• Original: J:353273 Eroglu B, et al., Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death. Cell Mol Life Sci. 2022 Mar 21;79(4):198
• All: 1 reference(s)