Nlrc4^em4Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nlrc4^em4Vnce
• Name: NLR family, CARD domain containing 4; endonuclease-mediated mutation 4, Russell E Vance
• MGI ID: MGI:7709165
• Synonyms: Nlrc4^-
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^em4Vnce page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A CRISPR/cas9-generated 10 bp deletion in exon 5 of the mouse Nlrc4 gene created a frame shift mutation and a premature stop codon at amino acid position 152 that results in a loss of protein function. The mutation was created in 129S1/SvImJ embryos. (J:298673)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 67 strains or lines available

References

• Original: J:298673 Mitchell PS, et al., NAIP-NLRC4-deficient mice are susceptible to shigellosis. Elife. 2020 Oct 19;9:e59022
• All: 1 reference(s)