Muc13^em1Gltr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Muc13^em1Gltr
• Name: mucin 13, epithelial transmembrane; endonuclease-mediated mutation 1, Alban Gaultier
• MGI ID: MGI:7707731
• Synonyms: Muc13^-
• Gene: Muc13 Location: Chr16:33614407-33640299 bp, + strand Genetic Position: Chr16, 24.21 cM
• Alliance: Muc13^em1Gltr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 technology, a guide RNAs with PAM sequences were designed to delete a 475 bp region in exon 2, including the start codon, of the mucin 13 (Muc13) gene. (J:101977, J:352635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc13 Mutation: 20 strains or lines available

References

• Original: J:352635 Rivet-Noor CR, et al., Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors. Brain Behav Immun. 2024 Apr 4;119:665-680
• All: 2 reference(s)