Syngap1^em1Syngp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Syngap1^em1Syngp
• Name: synaptic Ras GTPase activating protein 1 homolog (rat); endonuclease-mediated mutation 1, SynGAP Research Fund
• MGI ID: MGI:7705033
• Gene: Syngap1 Location: Chr17:27160227-27191408 bp, + strand Genetic Position: Chr17, 13.6 cM
• Alliance: Syngap1^em1Syngp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: The equivalent of the human p.Q503*, C>t mutation (Q503X, nucleotide change CAG to TAG) and three upstream silent mutations (TATATGAGACTG > TACATGAGGCTC) were introduced to exon 9 of the mouse Syngap1 gene using CRISPR/Cas9 methodologies in C57BL/6J embryos. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syngap1 Mutation: 50 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)