Gt(ROSA)26Sor^{tm16(CAG-Nsd2,-EBFP)Rsky}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm16(CAG-Nsd2,-EBFP)Rsky}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 16, Klaus Rajewsky
• MGI ID: MGI:7703662
• Synonyms: R26 MMSET^stopF
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm16(CAG-Nsd2,-EBFP)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340316
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm16(CAG-Nsd2,-EBFP)Rsky} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nsd2 (MGI:1276574)

• Mutation details: A targeting vector was designed with (from 5' to 3') a ubiquitously expressed CAG promoter, a loxP-flanked stop cassette containing a neomycin resistance (neo) cassette, nuclear receptor binding SET domain protein 2 (Nsd2) cDNA, and a frt-flanked cassette containing an internal ribosome entry site (IRES) and an enhanced blue fluorescent protein (eBFP) sequence. (J:340316)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1058 strains or lines available

References

• Original: J:340316 Winkler W, et al., Mouse models of human multiple myeloma subgroups. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2219439120
• All: 1 reference(s)