Lypd1^{em1(HBEGF)Zyliu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lypd1^{em1(HBEGF)Zyliu}
• Name: Ly6/Plaur domain containing 1; endonuclease-mediated mutation 1, Zhiyong Liu
• MGI ID: MGI:7703105
• Synonyms: Lypd1-DTR
• Gene: Lypd1 Location: Chr1:125795359-125840838 bp, - strand Genetic Position: Chr1, 54.7 cM
• Alliance: Lypd1^{em1(HBEGF)Zyliu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Lypd1^{em1(HBEGF)Zyliu} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Using CRISPR/Cas9 technology, a 3xV5 tag, a P2A self-cleaving peptide, and the human diphtheria toxin receptor (DTR) sequence immediately upstream of the endogenous stop codon of the Ly6/Plaur domain containing 1 (Lypd1) gene. Of note, besides being correctly targeted into the Lypd1 locus as designed, the targeting vector was randomly inserted in one unknown location in the mouse genome. (J:101977, J:351382)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lypd1 Mutation: 16 strains or lines available

References

• Original: J:351382 Zhang D, et al., Lypd1-DTR/+: A New Mouse Model for Specifically Damaging the Type Ic Spiral Ganglion Neurons of the Cochlea. Neurosci Bull. 2023 Sep;39(9):1459-1462
• All: 2 reference(s)