Gt(ROSA)26Sor^{tm2(CAG-SOX8)Vlf}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-SOX8)Vlf}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Veronique Lefevbre
• MGI ID: MGI:7665208
• Synonyms: R26^SOX8
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-SOX8)Vlf} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350915
• Parent Cell Line: C2 (Jaenisch) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CAG-SOX8)Vlf} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOX8 (30812)

  Sox8	(MGI:98370)

• Mutation details: The targeting vector was designed to insert (from 5' to 3') a ubiquitously expressed CAG promoter, a loxP-flanked stop cassette containing a neomycin resistance (neo) cassette and three polyadenylation signals, and 3xFLAG tagged human SRY (sex determining region Y)-box 8 (SOX8) cDNA sequence followed by a polyadenylation signal into the Gt(ROSA)26Sor locus. (J:350915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1042 strains or lines available

References

• Original: J:350915 Molin AN, et al., Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2316969121
• All: 1 reference(s)