Sox8^tm1.1Vlf
Targeted Allele Detail

Summary

• Symbol: Sox8^tm1.1Vlf
• Name: SRY (sex determining region Y)-box 8; targeted mutation 1.1, Veronique Lefebvre
• MGI ID: MGI:7665205
• Synonyms: Sox8^fl
• Gene: Sox8 Location: Chr17:25784865-25789666 bp, - strand Genetic Position: Chr17, 12.69 cM
• Alliance: Sox8^tm1.1Vlf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350915
• Parent Cell Line: C2 (Jaenisch) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The cassette comprising of a frt site followed by a lacZ sequence and a loxP site, then followed by a neomycin resistance (neo) cassette, a second frt site, and a second loxP site were inserted at position upstream of exon 2 of the Sox8 gene. A third loxP site was inserted downstream of exon 2. The frt-flanked lacZ and neo cassette were removed by crossing to FLPe mice. (J:350915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox8 Mutation: 27 strains or lines available

References

• Original: J:350915 Molin AN, et al., Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2316969121
• All: 1 reference(s)